Endocrine Abstracts

Testing for genetic markers is a promising approach in early diagnosis of type 1 diabetes mellitus (DM1). Of all DM1-associated genes and genetic loci, after HLA class II, insulin promoter gene confers the highest risk for the onset of disease with the burdened familial history for diabetes mellitus.Materials and methodsGenealogical analysis was used to identify the hereditary nature of the disease. DNA samples from 94 Uzbek patien...

Diabetes mellitus (DM) is a most significant medical-social worldwide problem. Absence of reliable screening program for identification of persons with the higher risk of DM dictates a necessity of sensitive tests of early DM diagnosis. Following genealogical analysis, two experimental groups were formed; patients with type 1 DM with the familial burden (probands) and those at risk (siblings) were included into the 1st and 2nd groups, respectively. Apparently healthy subjects ...